Synthesis of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)aceta

Details Synthesis of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)aceta Synthesis of N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)aceta

1997-12-12

1998-09-15

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C23315

Patent

active

058081526

ABSTRACT:
The present invention relates to a process for making N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide. The process includes the steps of (a) reacting 2-chloro-N-(4-fluorophenyl)-N-(1-methylethyl)acetamide with sodium formate to form a reaction mixture that contains N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamideformate; (b) adding an aprotic, aromatic solvent to the reaction mixture; (c) hydrolyzing the N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamideformate in the reaction mixture and (d) recovering N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide from the organic phase.

REFERENCES:
patent: 4334073 (1982-06-01), Diehr
patent: 5101304 (1992-03-01), Schmidt
patent: 5631403 (1997-05-01), Dierdorf

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