Synthesis of myo-inositol phosphates

Details Synthesis of myo-inositol phosphates Synthesis of myo-inositol phosphates

1997-02-04

1998-05-26

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

558161, 568833, C07D31770, C07F 902

Patent

active

057567743

ABSTRACT:
Provided herein are novel syntheses of the phosphate-based inositol derivatives itol (D4P), D-myo-inositol 1,4,5-trisphosphate (D-IP.sub.3), 6-O-benzyl-2,3:4,5-di-O-isopropylidene-myo-inositol H-phosphonate ((-)-3-HP) and L-myo-inositol 1,4,5-trisphosphate (L-IP.sub.3). These syntheses employ fewer column chromatography steps for the isolation of intermediates than do prior art syntheses, and hence, are more convenient, economical and efficient than are the previously known synthetic methods.

REFERENCES:
patent: 4873355 (1989-10-01), Hobbs
patent: 5260472 (1993-11-01), Chen
Aguilo, A. et al., The Regioselective Synthesis of Enantiomerically Pure myo-inositol derivatives. Efficient Synthesis of myo-inositol 1,4,5-trisphosphate. Tetrahedron Lett vol. 33, pp. 401-404, 1992.
de la Prada et al., Improved Preparation of acetals of myo-inositol and its (.+-.)--1--(.+-.)-1--benzyl ether;--Carbohydrates Research vol. 207, pp. 249-257, 1990.

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