Synthesis of methotrexate-containing heterodimeric molecules

Details Synthesis of methotrexate-containing heterodimeric molecules Synthesis of methotrexate-containing heterodimeric molecules

2007-06-12

2007-06-12

Rao, Deepak (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Plural nitrogens bonded directly to the pteridine ring system

C514S250000

Reexamination Certificate

active

10651340

ABSTRACT:
The present invention relates to novel compositions of methotrexate-containing heterodimeric probe molecules, also known as chemical inducers of dimerization (CID), useful in three-hybrid assays. The invention further relates to synthesis of said compositions and their intermediates. Another aspect of the invention is a method for using the heterodimeric probe molecules described herein in drug screens to identify potential protein targets to a given ligand, optimize protein-ligand interactions, or identify potential ligands for a given protein target. In certain embodiments, the invention contemplates the synthesis of the following methotrexate-containing heterodimeric probe:

REFERENCES:
patent: 2003/0165873 (2003-09-01), Come et al.
patent: 2004/0043388 (2004-03-01), Come et al.
patent: 2004/0266854 (2004-12-01), Becker et al.
patent: WO-01/017614 (2001-03-01), None
patent: WO-02/020715 (2002-03-01), None
Piper, J. R.; Montgomery, J. A.; Sirotnak, F. M.; Chello, P. L., Journal of Medicinal Chemistry, 25(2), 182-7 (English) 1982.
Knepper, T.; Przybylski, M.; Ahlers, M.; Ringsdorf, H. Chem. Biol. Pteridines, 1989 Proc. Int. Symp. Pteridines Folic Acid Deriv., 9th, Meeting Date 1989, 1280-3. Editor(s): Curtius, Hans-Christoph et al de Gruyter: Berlin, Fed. Rep. Ger. (English) 1990.
Liu, Jianquan; Wooley, Karen L. Polymeric Materials Science and Engineering, 84, 967-968 (English) 2001.
Antonjuk, David J.; Boadle, Deborah K.; Cheung, H. T. Andrew; Tran, Trung Q., Journal of the Chemical Society, Perkin Transactions,1: Organic and Bio-Organic Chemistry (1972-1999) (9), 1989-2003 (English) 1984.
Kevin Davies, “Counting the Cost of Drug Discovery”, BIO-IT World [online] Jul. 11, 2002, [retrieved on Oct. 13, 2005]. Retrieved from the internet, <http://www.bio-itworld.com/archive/071102/firstbase.html>.
Anomalous, “Drug Development: The Short Story 8. Combining the Figures and 6.”, Network Sci. [online] 2004, [retrieved on Oct. 13, 2005]. Retrieved from the Internet, <http://www.netsci.org/scgi-bin/Courseware/projector.pl?Course—num=course1&Filename=sli=.
Cheung et al., “N-(L-α-Aminoacyl) Derivatives of Methotrexate,” Heterocycles 28(2):751-758 (1989).

Affiliated with

Also associated with

Rating

Synthesis of methotrexate-containing heterodimeric molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of methotrexate-containing heterodimeric molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of methotrexate-containing heterodimeric molecules will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3838556