Synthesis of macrocyclic polyaminocarboxylates and their use for

Details Synthesis of macrocyclic polyaminocarboxylates and their use for Synthesis of macrocyclic polyaminocarboxylates and their use for

1993-04-02

1995-06-27

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D25700

Patent

active

054281563

ABSTRACT:
A simple method for the synthesis of 1,4,7,10-tetraazacyclododecane N,N'N",N'"-tetraacetic acid and 1,4,8,11-tetraazacyclotetradecane N,N',N",N'"-tetraacetic acid involves cyanomethylating 1,4,7,10-tetraazacyclododecane or 1,4,8,11-tetraazacyclotetradecane to form a tetranitrile and hydrolyzing the tetranitrile. These macrocyclic compounds are functionalized through one of the carboxylates and then conjugated to various biological molecules including monoclonal antibodies. The resulting conjugated molecules are labeled with radiometals for SPECT and PET imaging and for radiotherapy.

REFERENCES:
patent: 2407645 (1946-09-01), Bersworth
patent: 4168265 (1979-09-01), Tabushi et al.
patent: 4602106 (1986-07-01), Blanc
patent: 4639365 (1987-01-01), Sherry
patent: 4678667 (1987-07-01), Meares et al.
patent: 4880008 (1989-11-01), Lauffer
patent: 4885153 (1989-12-01), Wilbur et al.
patent: 4889931 (1989-12-01), Rocklage et al.
patent: 4923985 (1990-05-01), Gansow et al.
patent: 5021571 (1991-06-01), Mease et al.
patent: 5049667 (1991-09-01), Schaefer et al.
patent: 5053503 (1991-10-01), Dean et al.
patent: 5082599 (1992-01-01), Oftring et al.
patent: 5089663 (1992-02-01), Mease et al.
patent: 5101041 (1992-03-01), Troutner et al.
patent: 5132409 (1992-07-01), Felder et al.
patent: 5316757 (1994-05-01), Sherry et al.
Solomons, Organic Chemistry, 4th Ed., 1986, p. 849.
Cox et al., J. Chem. Soc., Chem. Comm., 1989, pp. 797-798.
Wu et al., Nucl. Med. Biol. vol. 19(2), 1992, pp. 239-244.
The Merke Index, 11th Ed., 1989, p. 63.
Marsden, Solvents Guide, 1963, pp. 9-15.
J. F. Desreux, Inorg. Chem. 19:1319-1324 (1980).
R. G. Buckley and F. Searle, FEBS Letters 166: 202-204 (1984).
M. K. Moi, et al., Analytical Biochemistry 148:249-253 (1986).
M. K. Moi and C. F. Meares, J. Am. Chem. Soc. 110:6266-6267 (1988).
M. Magerstadt, et al., Magnetic Resonance in Medcine 3:808-812 (1986).
J. P. L. Cox et al., J. Chem. Soc. Chem. Commun. 1989: 797-798 (1989).
C. F. Meares, et al. Br. J. Cancer 62(Suppl.X):21-26 (1990).
P. F. Sieving, et al., Bioconjugate Chem. 1:65-71 (1990).
M. J. McCall, et al., Bioconjugate Chem. 1:222-226 (1990).
S. V. Deshpande, et al., J. Nucl. Med. 31:473-479 (1990).
O. A. Gansow, Nucl. Med. Biol. 18:369-381 (1991).
S. J. Kline, Bioconjugate Chem. 2:26-31 (1991).
D. D. Dischino, et al., Inorg. Chem. 30: 1265-1269 (1991).
C. Wu, et al., Nucl. Med. Biol. 19:239-244 (1992).
S. C. Srivastava et al., IXth International Symposium on Radiopharmaceutical Chemistry, Paris, France, Apr. 6-10, 1992.
Mease, et al., J. Nucl. Med. 33:942 (May, 1992).
S. C. Srivastava, et al., J. Nucl. Med. 33:1030 (May, 1992).

Affiliated with

Also associated with

Rating

Synthesis of macrocyclic polyaminocarboxylates and their use for does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of macrocyclic polyaminocarboxylates and their use for, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of macrocyclic polyaminocarboxylates and their use for will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-288601