Synthesis of locked nucleic acid derivatives

Details Synthesis of locked nucleic acid derivatives Synthesis of locked nucleic acid derivatives

2003-05-08

2009-08-04

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S277000, C544S272000, C544S311000, C544S314000, C544S317000, C514S274000

Reexamination Certificate

active

07569575

ABSTRACT:
The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilizing intermediates that also can produce other LNA analogues such as oxy-LNA. Also, the compounds of the formula X are important intermediates that may be reacted with varieties of nucleophiles leading to a wide variety of LNA analogues.

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