Synthesis of leucovorin

Details Synthesis of leucovorin Synthesis of leucovorin

1980-12-22

1985-02-19

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D47504

Patent

active

045007110

ABSTRACT:
In the synthesis of calcium leucovorin (calcium 5-formyl-5,6,7,8-tetrahydrofolate), the use of an amine base in the conversion of anhydroleucovorin (5,10-methenyl-5,6,7,8-tetrahydrofolic acid) to leucovorin unexpectedly results in a pure (USP) product directly from the reaction mixture.

REFERENCES:
patent: 2741608 (1956-04-01), Shive

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