Synthesis of isopenicillin derivatives in the absence of living

Details Synthesis of isopenicillin derivatives in the absence of living Synthesis of isopenicillin derivatives in the absence of living

1979-05-17

1981-02-03

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-4-aza-bicyclo

435926, C12P 3700, C12R 175

Patent

active

042489660

ABSTRACT:
Isopenicillin derivatives having antimicrobial properties and a general formula of: ##STR1## where R, R.sub.1, and R.sub.2 are hydrogen, methyl, ethyl, propyl, isopropyl, or halogenated methyl, ethyl, propyl or isopropyl radicals and R.sub.3 is ##STR2## are produced in a cell-free system using an extract from Cephalosporium acremonium. The starting materials for the synthesis consist of tripeptides composed of unsubstituted or .beta.-substituted D-valine, unsubstituted or substituted L cysteine, and L- .alpha.-aminoadipic acid or its analogues. Certain enzymes in the cell-free extract are inactivated so that conversion does not proceed past the isopenicillin stage.

REFERENCES:
patent: 4002530 (1977-01-01), Troonen et al.
Troonen et al., "RIT 2214, A New Biosynthetic Penicillin Produced by a Mutant of Cephalosporium Acremonium", in The Journal of Antibiotics, Dec. 1976, pp. 1258-1267.

Affiliated with

Also associated with

Rating

Synthesis of isopenicillin derivatives in the absence of living does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of isopenicillin derivatives in the absence of living , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of isopenicillin derivatives in the absence of living will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-551494