Synthesis of intermediates for tetramisole, levamisole and their

Details Synthesis of intermediates for tetramisole, levamisole and their Synthesis of intermediates for tetramisole, levamisole and their

1981-10-01

1986-10-28

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D51304

Patent

active

046200096

ABSTRACT:
A process for the manufacture of 1-(2-alkoxyethyl)-4-phenyl-4-imidazolin-2-ones, 1-(2-alkoxyethyl)-4-phenyl-2-imidazolidones, 1-(2-alkoxyethyl)-4-phenyl-imidazolidine-2-thiones, certain of the corresponding 1-(2-hydroxyethyl) derivatives and their 3-acylated derivatives, and certain related compounds which are all useful as intermediates in a new process for the manufacture of tetramisole, dl-2,3,5,6-tetrahydro-6-phenylimidazo-[2,1-b]thiazole, and its derivatives. The compound tetramisole is useful as an anthelmintic.

REFERENCES:
patent: 2441935 (1948-05-01), Duschinsky
patent: 4310672 (1982-01-01), Raghu
patent: 4370482 (1983-01-01), Raghu et al.
Allen et al, J. Org. Chem., 28, 2759 (1963).
March, Advanced Organic Chemistry, pp. 377-379 (1977).
Hofmann, Imidazole, pp. 63-65 (1953).
Fiesen et al, Reagents for Organic Synthesis, Part I, p. 870, Part 3, p. 226, Part 5, 534 (1972).

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