Synthesis of inhibitors of p90Rsk

Details Synthesis of inhibitors of p90Rsk Synthesis of inhibitors of p90Rsk

2006-01-10

2009-10-20

McIntosh, III, Traviss C (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S018600, C536S124000

Reexamination Certificate

active

07605241

ABSTRACT:
The synthesis of the naturally occurring kaempferol glycoside SLO1O1-1, as well as analogs thereof, has been accomplished, as has its biochemical evaluation. SLO1O1-1 exhibits selective and potent p90 Rsk inhibitory activity at nanomolar concentrations without inhibiting the function of upstream kinases such as MEK, Raf, or PKC. The synthetic scheme of the invention verified the structural assignment of the natural product and has provided access to material sufficient for detailed biological evaluation.

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