Synthesis of inhibitors of calmodulin-mediated enzymes including

Details Synthesis of inhibitors of calmodulin-mediated enzymes including Synthesis of inhibitors of calmodulin-mediated enzymes including

1992-01-15

1995-01-31

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536116, 536118, 536119, 536120, 536124, 536125, C07H 100, C07H 1302

Patent

active

053860195

ABSTRACT:
The total synthesis of a group of compounds with inhibitory effects on calmodulin-mediated enzyme activities has been accomplished. Among these synthesized compounds are KS-501 and KS-502. Other compounds that have been synthesized by the described scheme are ent-KS-501 and ent-KS-502 which are enantiomers of KS-501 and KS-502 and which also have inhibitory effects on calmodulin-mediated enzyme activities.

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