Synthesis of indolizidines related to the carditonic pumiliotoxi

Details Synthesis of indolizidines related to the carditonic pumiliotoxi Synthesis of indolizidines related to the carditonic pumiliotoxi

1984-06-21

1987-06-23

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546183, A61K 31475, C07D22102

Patent

active

046753257

ABSTRACT:
A method of making dendrobatid alkaloids with the formula ##STR1## in which A is either CH.sub.3 or H, and n is an integer from 1-9, and R is CH.sub.2 OH, CHO, ##STR2## and R.sub.1 and R.sub.2 are alkyl groups; and the use of such alkaloids to treat cardiovascular illness.

REFERENCES:
Overman, Grant Application HL2585404, issued Jun. 14, 1983.
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Mensah-Dwumah et al., Toxicon, 1978, 16, 189.
Mensah-Dwumah et al., Chem. Abst. 89-101361 M(1978), eq. Toxicon, 1978, 16, 189.
Overman et al., J. Am. Chem. Soc. 1981, 103, 1851-1853.
Torregrosa et al., Tetrahedron, vol. 38, No. 15, pp. 2355-2363 (1982).
Albuquerque et al., Chem. Abst. 98:49103y.
Uemura et al., Chem. Abst. 98:89705c.
Overman et al., Chem. Abst. 95:25362u.
Daly et al., Chem. Abst. 90:81807b.
Tamburini et al., Chem. Abst. 95:198684d.
Daly et al., Chem. Abst. 92:215600f.
Overman et al., American Chemical Society, Washington D.C., 1980, Abstract paper, ORGN 25.
Tamburini, R. et al., "Inhibition of Calcium-Dependent ATPase from Sarcoplasmic Reticulum by a New Class of Indolizidine Alkaloids, Pumiliotoxins A, B, and 251D", Journal of Neurochemistry, (1981) 37(3):775-780.
Witkop, B., and E. Gossinger, The Alkaloids, (24:200), Eds. Arnold & Brossi.

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