Synthesis of immunologic, therapeutic and prophylactic compounds

Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Bacteria or actinomycetales

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424 932, 424 93461, 4241841, 4242241, 435 691, 435 693, 4351721, 435 711, 435 712, 435410, 435419, 4352523, 530350, 536 237, 800279, 800288, 800298, A01H 400, A61K 3900, C07K 1400, C12N 504

Patent

active

059355700

ABSTRACT:
A process for the synthesis and delivery of bioactive compounds, compounds that have a therapeutic, biochemical, or immunologic, effect on an animal, such as human. In the process, clavibacter is genetically altered so that it synthesizes the bioactive compound. A plant may be infected with the genetically altered clavibacter and used an as oral delivery system.

REFERENCES:
patent: 5415672 (1995-05-01), Fahey et al.
patent: 5446127 (1995-08-01), Garcia-Olmedo et al.
patent: 5468483 (1995-11-01), Thompson et al.
patent: 5580852 (1996-12-01), Putnam et al.
patent: 5588862 (1996-12-01), Corbin et al.
patent: 5612487 (1997-03-01), Lam et al.
Moffat Science 268:659-660, Exploring Transgenic Plants as a New Vaccine Source, 1995.
International Search Report, International Application No. PCT/US96/16638.
Lampel et al Applied & Environmental Microbiology 60:501-508, 1994.
Cardenas et al., "Oral Immunization Using Live Attenuated Salmonella spp. as Carriers of Foreign Antigens," Clinical Microbiology Reviews, pp. 328-342 (1992).
Carrier et al., "Expression of Human IL-1.beta. in Salmonella typhimurium A Model System for the Delivery of Recombinant Therapeutic Proteins in Vivo," The Journal of Immunology, vol. 148, pp. 1176-1181 (1992).
Charles et al., "Gene Expression and the Development of Live Enteric Vaccines," TIBTECH, pp. 117-121 (1990).
Doggett et al., "Immune Responses to Streptococcus sobrinus Surface Protein Antigen A Expressed by Recombinant Salmonella typhimurium," Infection and Immunity, vol. 61, pp. 1859-1866 (1995).
Medical Application, "Exploring Transgenic Plants as a New Vaccine Source," Science, vol. 268, pp. 658-660 (May, 1995).
Zhen Fang Fu et al., "Rabies virus nucleoprotein expressed in and purified from insect cells is efficacious as a vaccine," Proc. Natl. Acad. Sci., vol. 88, pp. 2001-2005 (1991).
Zhen Fang Fu et al., "Oral vaccination of raccoons (Procyon lotor) with baculovirus-expressed rabies virus glycoprotein," Vaccine, vol. 11, pp. 925-928 (1993).
Haq et al., "Oral Immunization with a Recombinant Bacterial Antigen Produced in Transgenic Plants," Science, vol. 268, pp. 714-716 (1995).
Ianaro et al., "Expression of TGF-.beta. in attenuated Salmonella typhimurium: oral administration leads to the reduction of inflammation, IL-2 and IFN-.gamma., but enhancement of IL-10 in carrageenin-induced oedema in mice," University of Glasgow, pp. 8-15 (1994).
Crop Genetics International, "InCide.TM. Biopesticides Technical Manual," pp. 1-11.
Kraehenbuhl et al., "Molecular and Cellular Basis of Immune Protection of Mucosal Surfaces," Physiological Reviews, vol. 72, pp. 853-879 (1992).
Curtiss III, et al., "Selective Delivery of Antigens by Recombinant Bacteria," New Strategies for Oral Immunization, pp. 35-49 (1989).
Warren E. Leary, The New York Times, America Online:MHandP, pp. 1-3 (1995).
Medaglini et al., "Mucosal and systemic immune responses to a recombinant protein expressed on the surface of the oral commensal bacterium Streptococcus gordonii after oral colonization," Proc. Natl. Acad. Sci., vol. 92, pp. 6868-6872 (1995).
Pozzi et al., "Delivery and Expression of a Heterologous Antigen on the Surface of Streptococci," Infection and Immunity, vol. 60, pp. 1902-1907 (1992).
Research News, "Triggering the First Line of Defense," Science, vol. 265, pp. 1522-1524 (1994).
Tacket et al., "Comparison of the Safety and Immunogenicity of .increment.arocC .increment.aroD and .increment.cya .increment.crp Salmonella typhi Strains in Adult Volunteers," Infection and Immunity, vol. 60, pp. 536-541 (1992).
Turner et al., "Endophytes: An Alternative Genome for Crop Improvement," International Crop Science I. (1993) Crop Science Society of America, Madison, WI.
Thanavala et al., "Immunogenicity of transgenic plant-derived hepatitis B surface antigen," Proc. Natl. Acad. Sci., vol. 92, pp. 3358-3361 (Apr., 1995).
Steven C. Witt, "Case Study: Crop Genetics International," Biotechnology, Microbes and the Environment, Briefbook, pp. 63-85 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Synthesis of immunologic, therapeutic and prophylactic compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of immunologic, therapeutic and prophylactic compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of immunologic, therapeutic and prophylactic compounds will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1117548

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.