Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Patent
1999-06-09
2000-07-25
Celsa, Bennett
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
530331, 530334, 525 5411, 525374, 525377, 560312, C07K 104, C08G 6348
Patent
active
06093798&
ABSTRACT:
The present invention describes solid phase reaction products of a solid substrate carrying a plurality of covalently bound hydroxylamine or protected hydroxylamine groups of formula (A) or (B): ##STR1## where P.sub.1 is hydrogen or an amino protecting group, P.sub.2 is hydrogen or a hydroxyl protecting group, and the bond designated (a) covalently links the formula (A) or (B) to the residue of the solid substrate, and is cleavable under acid conditions or by photolysis. The solid phase reaction products can be used for the synthesis of hydroxamic acid derivatives or a combinatorial library of such compounds.
REFERENCES:
patent: 4461876 (1984-07-01), Lieberman
patent: 4868248 (1989-09-01), Sparapany
Chemical Abstracts, vol. 77, No. 24 (Dec. 11, 1972), Abstract No. 153114e, Chernyshev, "Maleic Anhydride Copolymer," p. 39, col. 2, and SU A 342 865 (Institute of Fine Chemical Technology, Moscow) Jun. 22, 1972.
Polymer Bulletin, vol. 32, No. 3, pp. 273-279 (1994) XP002003868, Taek Seung Lee, "Synthesis of Porous Poly(Hydroxamic Acid) from Poly(Ethyl Acrylate Co-Divinylbenzene)."
Floyd Christopher David
Lewis Christopher Norman
British Biotech Pharmaceuticals Limited
Celsa Bennett
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