Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-01-12
2009-06-02
Morris, Patricia L (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07541471
ABSTRACT:
The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer.An example of a step in the synthesis of such a himbacine analog is as follows:
REFERENCES:
patent: 6063847 (2000-05-01), Chackalamannil et al.
patent: 6326380 (2001-12-01), Chackalamannil et al.
patent: 6645987 (2003-11-01), Chackalamannil et al.
patent: 7235567 (2007-06-01), Wu
patent: 7304078 (2007-12-01), Chackalamannil et al.
Chackalamannil, S., et. al.; “Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents”, J. Med. Chem, Sep. 22, 2005; vol. 48, No. 19, pp. 5884-5887, web published Aug. 24, 2005.
Clasby, M. C., et. al; “Discovery & Synthesis of novel series of quinoline-based thrombin reecptor (PAR-1) antagonists” Bioorganic and Medicinal Letters; Mar. 15, 2006; vol. 16, No. 6; pp. 1544-1548; web published Dec. 27, 2005.
Hatayama, K., et. al.; “Production of optically active propargy alcohol derivs. - e.g.alkoxy-hydroxy-butyne or deriv., by acylating in presence of enzyme”; Derwent; Abstract; 1996 - 040245; 2 pages.
Tao, B. et. al.; “Nonenzymatic Kinetic Resolution of Propargylic Alcohols by a Planar-Chiral DMAP Derivative: Crystallographic Characterization of the Acylated Catalyst”; J. Am. Chem. Soc.; 1999; 121; pp. 5091-5091; web published May 14, 1999.
Chiu John S
Fu Xiaoyong
Lee Hong-Chang
Liao Jing
Thiruvengadam Tiruvettipuram K
Morris Patricia L
Patent Practitioners of Schering Corporation
Schering Corporation
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