Synthesis of hGRF (somatocrinin) in liquid phase and intermediat

Details Synthesis of hGRF (somatocrinin) in liquid phase and intermediat Synthesis of hGRF (somatocrinin) in liquid phase and intermediat

1985-07-08

1987-11-17

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

C07K 710

Patent

active

047075414

ABSTRACT:
A process for the synthesis, in liquid phase and by fragments, of hGRF 1-44 and hGRF 1-40. This process consists in coupling, one after the other and in the order of the sequence of the GRF,

REFERENCES:
patent: 4415558 (1983-11-01), Vale, Jr. et al.
patent: 4489163 (1984-12-01), Rivier et al.
patent: 4517181 (1985-05-01), Ling et al.
patent: 4529595 (1985-07-01), Rivier et al.
patent: 4549986 (1985-10-01), Evans et al.
Chem. Pharm. Bull. 32, No. 2, 739-743, 510-519, 520-529, 1193-1199 (1984).
Chemical Abstract, vol. 101, 1984, p. 80 Ref. No. 104311x, Columbus, Ohio U.S.; N. Ling et al.: "Isolation, Primary Structure, and Synthesis Of Human Hypothalamic Somatocrinin: Growth Hormone-Releasing Factor"& Proc. Natl. Acad. Sci. U.S.A. 1984, 81 (14), 4302-4306.
Chemical Abstracts, vol. 101, 1984, p. 86 Ref. No. 144228g, Columbus, Ohio, U.S. R. Guillemin et al.: Recent Prog. Horm. Res. 1984, "Somatocrinin, The Growth Hormone-Releasing Factor".
Chemical & Pharmaceutical Bullentin, vol. 32, No. 2, Fevrier 1984, pp. 520-529; Nobutaka Fujii et al.: "Studies On Peptides, CXVII. Solution Synthesis Of The Tetratetracontapeptide Amide Corresponding To The Entire Amino Acid Swquence Of Growth Hormone Releasing Factor, Somatocrinin".

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