Synthesis of hexahydrolupulone, novel forms thereof, and its use

Details Synthesis of hexahydrolupulone, novel forms thereof, and its use Synthesis of hexahydrolupulone, novel forms thereof, and its use

1991-06-05

1992-11-24

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 49713

Patent

active

051664496

ABSTRACT:
A process for making hexahydrolupulone is described which involves the separation of beta acids from a hop extract, the removal of catalyst poisons from the beta acids, the hydrogenation of the beta acids to hexahydrolupulone, and the purification of the resulting hexahydrolupulone. Its use as an inhibitor of the growth of unwanted types of cells is described, as well as preferred forms for such use.

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patent: 4160787 (1979-07-01), Moll et al.
patent: 4324810 (1982-04-01), Goldstein et al.
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Siaens et al., Chem. Abst., vol. 87, #85,152v (1977).
Keukeleine et al., Chem. Abst., vol. 86, #4583r (1977).

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