Synthesis of galactosylhydroxylysine

Details Synthesis of galactosylhydroxylysine Synthesis of galactosylhydroxylysine

1996-08-30

1998-10-20

Knode, Marian C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 172, 536 179, 536 185, 536124, 530395, C07H 1504, A61K 3170

Patent

active

058247866

ABSTRACT:
Galactosylhydroxylysine is a terminal degradation product of the bone matrix which thus serves as biochemical marker of bone resorption. A method of synthesizing galactosylhydroxylysine is provided. Antibodies against this synthetically prepared galactosylhydroxylysine conjugated to protein carriers were raised to establish methods to measure galactosylhydroxylysine in biological fluids. The antibodies of the invention recognize native galactosylhydroxylysine and are, for example, useful in the measurement of galactosylhydroxylysine as a biochemical marker of bone resorption in biological fluids. Testing of human serum or adolescent urine resulted in dose-dependent increases in signal intensity using the method of the invention.

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Ju et al., "Development of an Immunoassay for Galactosylhydroxylysine," Abstract S407, Journal of Bone and Mineral Research, p. S191 (Aug. 1996), from the 18th Annual Meeting of the Anerican Society for Bone and Mineral Research, Seattle, Washington, Sep. 7-12, 1996.
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