Synthesis of fluorobenzaldehydes

Details Synthesis of fluorobenzaldehydes Synthesis of fluorobenzaldehydes

1991-07-31

1992-08-11

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568425, 568426, 568437, C07C 4545, C07C 4755

Patent

active

051380994

ABSTRACT:
4-fluorobenzaldehydes are formed from compounds of the formula (I) ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different, and represent H, halogen, or an alkyl group of from 1 to about 10 carbon atoms, wherein, when at least one of R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is halogen, at least one of remaining R.sub.1, R.sub.2, R.sub.3 or R.sub.4 is alkyl. the compound of formula of (I) is reacted with a formylating agent in the presence of FeCl.sub.3 in a reaction mixture, from which is separated a compound of the formula (II) ##STR2## wherein R.sub.1, R.sub.2 , R.sub.3 and R.sub.4 are as defined above.

REFERENCES:
patent: 4588844 (1986-05-01), Kysela et al.
patent: 4845304 (1989-07-01), Yoshida et al.
Lewin et al., "Formulation of Arenes by . . . Procedures", Organic Preparations and Procedures Int., 10(5), 201-204 (1978).
Aslam et al., "Friedel-Crafts Acylations . . . Gattermann Formylation Reactions", J.C.S. Perkin 1, pp. 892-894.

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