Synthesis of estrogen-purine base and estrogen-mercapturate addu

Details Synthesis of estrogen-purine base and estrogen-mercapturate addu Synthesis of estrogen-purine base and estrogen-mercapturate addu

1996-04-19

1998-11-24

Feisee, Lila

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

552625, 536 261, 536 271, C07D47300, C07J 100

Patent

active

058408894

ABSTRACT:
Estrogen-nucleoside, estrogen-guanine and estrogen-mercapturate adducts are potential biomarkers for determining susceptibility of animals to a number of estrogen related cancers. These adducts may be used as biomarkers for determining risk of estrogen-induced cancers. A linker chemistry has been devised to couple these adducts to protein for production of immunogens, required for production of specific monoclonal antibodies.

REFERENCES:
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Jellinck, P.H. et al. 1969. Steroids 13(5): 711-718.
Knuppen, R. et al. 1972 Hoppe-Seyler's Z. Physiol. Chem. Bd 353, S. 565-568.
Liehr, J. 1994. Polycyclic Aromatic Cpds. 6: 229-239.
Han, X. et al. 1995. Carcinogenesis, 16: 2571-2574.
Numazawa, M. et al. 1989. Chem. Pharm. Bull 37(6): 1561-63.
Fujii et al. 1985. Steroids, 46: 857-865.
Pierce Chemical Co. 1992. p. 39: Immuno Technology Catalog & Handbook.

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