Synthesis of enantiomerically pure amino-substituted fused...

Details Synthesis of enantiomerically pure amino-substituted fused... Synthesis of enantiomerically pure amino-substituted fused...

2006-11-14

2008-11-18

Davis, Zinna N (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S143000, C546S152000, C546S159000

Reexamination Certificate

active

07452994

ABSTRACT:
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

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