Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
2006-05-31
2010-12-14
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
Reexamination Certificate
active
07851621
ABSTRACT:
A process for the synthesis of deoxybiotinyl hexamethylenediamine0-DOTA is herein described. Said process comprises reacting biotinyl hexamithylenediamine with tri-t-butyl DOTA in the presence of benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate, as the condensing agent, and triethylamine, as a base.
REFERENCES:
patent: 2005/0085630 (2005-04-01), Olejnik et al.
patent: WO 02/066075 (2002-08-01), None
Giuseppina Sabatino, et a., A New Biotin Derivative-Dota Conjugate as a Candidate . . . , J. Med. Chem. vol. 46, pp. 3170-3173, 2003.
Di Marzo Maria
Marzi Mauro
Jarrell Noble
Lucas & Mercanti LLP
Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
Wilson James O.
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