Synthesis of deoxybiotinyl hexamethylenediamine-dota

Details Synthesis of deoxybiotinyl hexamethylenediamine-dota Synthesis of deoxybiotinyl hexamethylenediamine-dota

2006-05-31

2010-12-14

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07851621

ABSTRACT:
A process for the synthesis of deoxybiotinyl hexamethylenediamine0-DOTA is herein described. Said process comprises reacting biotinyl hexamithylenediamine with tri-t-butyl DOTA in the presence of benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate, as the condensing agent, and triethylamine, as a base.

REFERENCES:
patent: 2005/0085630 (2005-04-01), Olejnik et al.
patent: WO 02/066075 (2002-08-01), None
Giuseppina Sabatino, et a., A New Biotin Derivative-Dota Conjugate as a Candidate . . . , J. Med. Chem. vol. 46, pp. 3170-3173, 2003.

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