Synthesis of D-3 phosphorylated phosphoinositides and analogues

Details Synthesis of D-3 phosphorylated phosphoinositides and analogues Synthesis of D-3 phosphorylated phosphoinositides and analogues

1999-07-27

2000-08-01

Ambrose, Michael G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558106, 558160, C07F 910

Patent

active

060969164

ABSTRACT:
Disclosed are unique starting materials, reaction sequences and intermediate compounds for the preparation of D-3-phosphorylated phosphoinositides (3-PPI) of unambiguous structure and absolute stereochemistry. The enantiomerically pure D-3-phosphorylated phosphoinositides also provided have many uses, including in the development of diagnostics and therapeutics based on the roles of 3-PPI in intracellular signaling.

REFERENCES:
Aneja, et al., "1D- and 1L-1,2:4,5-Di-.omicron.-cyclohexylidene-3-.omicron.-allyl-myo-inositols: Complementary Versatile New Starting Materials for Syntheses in the 1D-myo-Inositol Series," Tetrahedron Letters, vol. 37, No. 29, pp. 5081-5082, 1996.

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