Synthesis of cyclopropylacetylene

Details Synthesis of cyclopropylacetylene Synthesis of cyclopropylacetylene

1997-12-15

2000-02-22

Griffin, Walter D.

Chemistry of hydrocarbon compounds

Alicyclic compound synthesis

From nonhydrocarbon

585534, 585641, 585358, 585 20, C07C 126, C07C 128

Patent

active

060282371

ABSTRACT:
The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is a reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-ben zoxazin-2-one which is a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

REFERENCES:
patent: 5663467 (1997-09-01), Thompson et al.
Thompson et al. (1995) Tetrahedron Letters, vol. 36, No. 49: p. 8937-6940.

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