Synthesis of cyclopropylacetylene

Details Synthesis of cyclopropylacetylene Synthesis of cyclopropylacetylene

1995-01-23

1997-09-02

Caldarola, Glenn A.

Chemistry of hydrocarbon compounds

Alicyclic compound synthesis

From nonhydrocarbon

585534, C07C 1207

Patent

active

056634676

ABSTRACT:
An improved synthesis of cyclopropylacetylene involving cyclization of 5-halo-1-pentyne in strong base is disclosed, and is useful for preparing compounds with a cyclopropylethynyl substituent, such as an intermediate for a highly potent HIV reverse transcriptase inhibitor or other pharmaceutically active compounds.

REFERENCES:
Militzer, et al., "Versatile Syntheses of Alkynyl- and Substituted Alkynylcyclopropanes: 2-Alkoxyethynylcyclopropanes . . . ", Synthesis, pp. 998-1000 (1972). No Month Available.
Schoberth, et al., "Eine einfache Herstellungsmethode fur Cyclopropylacetylen", Communications, Dec. 1972, p. 703, No Month Available.
Sherrod, et al., "Generation and Rearrangements of the 1-Cyclopropylvinyl Cation . . . ", Organic and Biological Chemistry, pp. 1925-1940, (1971), No Month Available.
Mikhailov, et al., "Synthesis of Polycyclic Compounds", J. of Gen. Chem. of the U.S.S.R., vol. XXII, pp. 195-201, No Month Available.

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