Synthesis of cyclopropane amino acids

Details Synthesis of cyclopropane amino acids Synthesis of cyclopropane amino acids

1984-12-05

1986-12-16

Phillips, Delbert R.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

530329, 530330, 530331, C07K 508, C07K 510, C07K 706

Patent

active

046297847

ABSTRACT:
Cyclopropane ("Cyclopropyl") amino acids and peptides containing at least one cyclopropyl amino acid are disclosed. The processes for synthesizing cyclopropyl amino acids and peptides containing at least one cyclopropyl amino acid are also disclosed. Cyclopropyl amino acids are useful as enzyme inhibitors and as substitutes for natural amino acids in peptide hormones such as regulators of bodily functions to enhance bioactivity, to stabilize the peptide into which it is incorporated to cleavage by enzymes and to convert such peptides into enzyme inhibitors.

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