Synthesis of cyclopentene derivatives

Details Synthesis of cyclopentene derivatives Synthesis of cyclopentene derivatives

1990-04-06

1991-10-15

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

558260, 560231, 568834, 544276, C07C 3506, C07C 6996

Patent

active

050576305

ABSTRACT:
This invention relates to a new process for preparing certain optically active purine substituted cyclopentene derivatives including the antiviral agent, carbovir, and novel intermediates used in this process. In particular, this invention concerns a synthesis of (1R-cis)-4-hydroxymethyl-2-cyclopenten-1-ol, an intermediate in this process.

REFERENCES:
patent: 4916224 (1990-04-01), Vince et al.
March, J., Advanced Organic Chemistry, 3rd Ed., Chap. 4 John Wiley & Sons, New York, NY (1985).
Vince, R., et al., Biochem. Biophys. Res. Commun. 156 (2) 1046 (1988).
J. Am. Chem. Soc., 110, 621 (1988).
Synthesis, Sugai, T., et al., 19-22 (1988).
J.C.S. Perkin I, Bajorek, R., 1, 1243 (1974).

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