Synthesis of cyclic peptides

Details Synthesis of cyclic peptides Synthesis of cyclic peptides

1995-04-18

1997-01-21

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Oxytocin; vasopressin; related peptides

530338, 530344, C07K 102, C07K 118, C07K 716

Patent

active

055960782

ABSTRACT:
A process for preparing and purifying cyclic peptides having disulfide moieties in a single processing operation which simplifies synthesis and reduces production costs, yet produces high, quality yield. Higher yields are obtained by isolating the desired cyclic compound through direct ion exchange chromatography as an integral part of the single process. The improved process is particularly useful for the preparation of vasopressin and oxytocin and their respective derivatives and analogs.

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Article entitled "Titanium (III) as a Selective Reducing Agent for Nitroarginyl Peptides: Synthesis of Arginine Vasotocine," by Freidinger, J. Org. Chem., 43:4800-4803 (1978).

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