Synthesis of cyclic peptides

Details Synthesis of cyclic peptides Synthesis of cyclic peptides

1997-11-10

1999-11-23

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Oxytocin; vasopressin; related peptides

530338, 530344, C07K 102, C07K 118, C07K 120, C07K 716

Patent

active

059902736

ABSTRACT:
A process for preparing and purifying cyclic peptides having disulfide moieties in a two step processing operation including reverse phase chromatography which simplifies synthesis and reduces production costs, yet produces high, quality yield. The improved process is particularly useful for the preparation of vasopressin and oxytocin and their respective derivatives and analogs.

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