Synthesis of cross-links in the helical domain of collagen using

Details Synthesis of cross-links in the helical domain of collagen using Synthesis of cross-links in the helical domain of collagen using

1984-05-18

1985-10-01

Schain, Howard E.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Treating animal or plant material or micro-organism

260113, 260115, 2601237, 435 69, C07G 700, C08H 106, C08L 8906, C09H 700

Patent

active

045446385

ABSTRACT:
Aldehyde cross-link intermediates and cross-links are generated in the central helical portion of collagen by incubating collagen with pyridoxal-5-phosphate and either cupric copper ion or ferrous iron ion. The cross-links are chemically similar to natural cross-links found in the non-helical regions and are directly between amino-acid moieties naturally occuring in the central helical portion of collagen. Cross-linking and utilization of aldehyde intermediates occurs when the product is reincubated after pyridoxal is removed. Alternatively maintaining the product at body temperatures will promote cross-linking. The cross-linked collagen product has increased resistance to enzyme degradation.

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