Synthesis of compounds with biological activity, and methods of

Details Synthesis of compounds with biological activity, and methods of Synthesis of compounds with biological activity, and methods of

1990-02-16

1992-11-24

Richter, Johann

Implements or apparatus for applying pushing or pulling force

Portable implements or apparatus for tensioning flexible...

Including rotatably driven drum for engaging either material...

554223, 560261, 568687, C07C 6702, C07C 4100, C07C 4300

Patent

active

051663791

ABSTRACT:
This invention relates to the methods for the synthesis and use of acetylenic carbinols and their analogs, having various immunomodulatory properties in vitro and in vivo.

REFERENCES:
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Cimino, G., A. DeGiulio, S. De Rosa, S. De Stefano, and G. Sodano (1985) "Further High Molecular Weight Polyacetylens from the Sponge Petrosia ficiformis," J. Natural Products 48(1):22-27.
Quinoa, E., and P. Crews (1988) "Melynes, Polyacetylene Constituents from a Vanuatu Marine sponge," Tetrahedron Letters 29(17):2037-2040.
Cimino, G., A. Crispino, S. De Rosa, S. De Stefano, and G. Sodano (1981), "Polyacetylenes from the spongs Petrosia ficiformis found in dark caves," Experientia 37:924-926.
Fusetani, N., Y. Kato, S. Matsunaga, and K. Hashimoto (1983), "Bioactive Marine Metabolites III, A Novel Polyacetylene Alcohol, Inhibitor of Cell Division in Fertilized Sea Urchin Eggs, from the Marine Sponge Tetrosia sp.," Tetrahedron Letters 24(27):2771-2774.
Wright, A. E., O. K. McConnell, S. Kohmoto, May S. Lui, Winnie Thompson, and K. M. Snader (1987), "Duryne, a New Cytotoxic Agent from the Marine Sponge Cribrochalina dura," Tetrahedron Letters 28(13):1377-1380.
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Rotem, M., and Y. Kashman (1979) "New Polyacetylenes from the Spronge Siphonochalina sp.," Tetrahedron Letters 34:3193-3106.
Fusetani, N., M. Sugano, S. Matsunaga, and K. Hashimoto (1987) "H,K-ATPase Inhibitors from the Marine Sponge Siphonochalina truncata: Absolute Configuration of Siphonodial and Two Related Metabolites," Tetrahedron Letters 28(37):4311-4312.
Hansen, L., and P. M. Boll (1986) "Polyacetylenes in Araliaceae: Their Chemisty, Biosynthesis, and Biological Significance," Phytochemistry 25(2):285-293.
Canadian J. Microbiology, vol. 31, 129-133 (1985).
Shi et al. Chem. Abstract; vol. 108; No. 21; 187023y (1988).

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