Synthesis of combretastatin A-4 prodrugs and trans-isomers...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

Reexamination Certificate

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C514S079000, C536S026100, C536S055200, C546S134000, C546S152000, C546S348000, C558S089000, C562S008000

Reexamination Certificate

active

07018987

ABSTRACT:
The present invention relates to novel water-soluble, stable derivatives of combretastatin A-4, and novel synthesis methods therefore. The combretastatin A-4 prodrugs described herein appear to be useful in the treatment of neoplastic disease.

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