Synthesis of cholesterol-lowering agents

Details Synthesis of cholesterol-lowering agents Synthesis of cholesterol-lowering agents

1989-07-18

1991-12-10

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, 549374, 549375, C07F 708

Patent

active

050720023

ABSTRACT:
Processes of synthesizing compounds of the formula: ##STR1## wherein R.sub.1 is H, lower alkyl (1 to 6 C), lower dialkyl (1 to 6 C), lower cycloalkyl (3 to 7 C), or lower dicycloalkyl (3 to 7 C);

REFERENCES:
T. Rosen, et al., Tetrahedron, "Synthesis of Mevinic Acids," 42 (No. 18), pp. 4909-4951 (1986).
D. Clive et al., J. Am. Chem. Soc., "Total Synthesis of Both (+) Compactin and (+)-Mevinolin," 110 (No. 20), pp. 6914-6917 (1988).
J. McMurry et al., (I), J. Org. Chem., "Improved procedures for the reductive coupling . . . " 41 (No. 5), pp. 896-897 (1976).
J. McMurry et al.; (II), J. Org. Chem., "Titanium-induced reductive coupling of carbonyls to olefins," 43(17), pp. 3255-3266 (1978).
P. C. Anderson, et al.; Tet. Lett., "Synthetic studies related to compactin and mevinolin . . . , " 24 (No. 13), pp. 1373-1376 (1983).
M. Hirama, et al.; Tet. Lett., "Total synthesis of (+) Monacolin K (Mevinolin)," 24 (no. 17), pp. 1811-1812, (1983).
J. McMurry et al.; (III), J. Am. Chem. Soc., "A new method of reductive coupling of carbonyls to olefins," 96(14), pp. 4708-4709 (1974).
J. McMurry, Accounts Chemical Research, "Titanium--induced dicarbonyl coupling reactions," 16, pp. 405-411 (1983).

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