Chemistry: electrical and wave energy – Processes and products – Processes of treating materials by wave energy
Patent
1993-01-25
1994-06-07
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Processes of treating materials by wave energy
20415761, 436518, C07K 100
Patent
active
053186796
ABSTRACT:
The present invention is an improved method of making sequenced chemical chain compounds through the application of laser copy technology to UV light directed spatially addressed parallel chemical synthesis and is particularly useful in the production of numerous proteins of varying amino acid sequences on a restricted solid support. Chemical groups, such as amines, are attached to the surface of a solid sup- port, such as flat glass, and subjected to chemical reaction disposed to link chemical units to the attached groups that are protected from further reaction by photolabile groups. Such solid support and photolabile protected units are then selectively deprotected by irradiation with a UV laser beam. The support and attached units are then subjected to chemical reaction to link chemical units to the selectively deprotected units. By repeated such treatment it is possible to produce unlimited combinations of chain chemical units in less time and at greater efficiency than has previously been possible.
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Delacroix-Muirheid Cybille
H & N Instruments, Inc.
Millard Sidney W.
Niebling John
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