Synthesis of carbapenems using n-substituted azetidinones

Details Synthesis of carbapenems using n-substituted azetidinones Synthesis of carbapenems using n-substituted azetidinones

1985-08-15

1988-09-06

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540351, C07D48704

Patent

active

047694513

ABSTRACT:
A novel process is disclosed for converting known 3,4-disubstituted azetidinones to carbapenems. The process proceeds through novel N-substituted intermediates and then cyclizes to the 4-position of the azetidinone to form the carbapenem.

REFERENCES:
patent: 4208422 (1980-06-01), Christensen et al.
patent: 4234596 (1980-11-01), Christensen et al.
patent: 4318912 (1982-05-01), Christensen et al.
patent: 4383946 (1983-05-01), Christensen et al.
M. Anatani et al., Tetrahedron Letters, vol. 23, No. 38, pp. 3921-3924, (1982).
T. Kametani, Heterocycles, vol. 17, pp. 463, 495 and 496, (1982).

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