Synthesis of capsacin derivatives and their use as an analgesic

Details Synthesis of capsacin derivatives and their use as an analgesic Synthesis of capsacin derivatives and their use as an analgesic

1990-12-24

1992-03-10

Dees, Jose G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C09F 700

Patent

active

050947826

ABSTRACT:
Nonanoyl vanillylamide succinate was synthesized from synthetic capsaicin (nonanoyl vanillylamide) and succinic anhydride. The antinociceptive and cardiovascular effects of nonanoyl vanillylamide and its derivatives were investigated. We found that nonanoyl vanillylamide and nonanoyl vanillylamide succinate strongly inhibited the writhing response, led to the vascular smooth muscle relaxation, produces bradycardia and a fall of blood pressure. The potency of nonanoyl vanillylamide succinate was found to be slight greater than that of nonanoyl vanillylamide, when compared with the same molar dose/kg of their administrations.

REFERENCES:
Nelson, Journal of the American Chemical Society, vol. 45, pp. 2170-2181, 1923.

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