Synthesis of bisindolylmaleimides

Details Synthesis of bisindolylmaleimides Synthesis of bisindolylmaleimides

1998-05-19

1999-09-07

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540460, 540472, C07D49822, C07D48722

Patent

active

059489073

ABSTRACT:
The present invention provides for the reaction of optionally substituted indole-3-acetamides with optionally substituted methyl indole-3-glyoxyl reagent to prepare potent PKC inhibitors.

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patent: 5057614 (1991-10-01), Davis et al.
patent: 5399712 (1995-03-01), Hill
patent: 5541347 (1996-07-01), Faul et al.
patent: 5559228 (1996-09-01), Gillig et al.
patent: 5821365 (1998-10-01), Jirousek et al.
Davis et al., Inhibitors of Protein Kinase C. 1. 2,3-Bisarylmaleimides, J. Med. Chem. Jan. 1992, vol. 35, No. 1, pp. 177-184.

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