Synthesis of bisindolylmaleimides

Details Synthesis of bisindolylmaleimides Synthesis of bisindolylmaleimides

1994-10-03

1996-07-30

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Acyclic carbon bonded directly to three benzene rings or to...

552 1, 556414, 558 46, 558 47, 560111, 560160, 560266, 564183, 564224, 564462, 564508, 548478, C07C 4103

Patent

active

055413471

ABSTRACT:
The present invention provides a novel synthesis of the compounds of Formula (I): ##STR1## The compounds are produced in high yield and without utilizing expensive chromatographic separations. The synthesis is particularly advantageous because it is stereoselective.

REFERENCES:
patent: 4923986 (1990-05-01), Murakata et al.
patent: 5057614 (1991-10-01), Davis et al.
Rudloff, et al., "Hydrogenolysis of Carbohydrates", Canadian Journal of Chemistry, vol. 35, 315-321 (1957).
Rosenthal, et al., "The reaction of unsaturated carbohydrates with carbon monoxide and hydrogen. III. Structure and stereochemistry of the hexitols from 3,4-DI-O-ACETYL -D-Arabinal.", Canadian Journal of Chemistry,vol. 42, 2025-2027 (1964).
Derwent Abstract 90-132947/18; 21.10.88-DE-835842 (1988).
Derwent Abstract 92-274042/33;90.11.20 90JP-314628 (1990).
Meier, et al., Tetrahedron Letters, 34:33, 5277-5280 (1993).
Wilkinson, et al., Bichem. J.,294, 335-337 (1993).
Bit, et al., J. Med. Chem.,36, 21-29 (1993).
Martiny-Baron, et al., The Journal of Biological Chemistry,268:13, 9194-9197 (1993).
Krakowiak, et al, SYNLETT, 611-620, (Sept. 1993).
Mulqueen, et al., Agents Actions,37, 85-89 (1992).
Davis, et al., J. Med. Chem.,35, 177-184 (1992).
Davis, et al., J. Med. Chem.,35, 994-1001 (1992).
Toullec, et al., The Journal of Biological Chemistry,226:24, 15771-15781 (1991).
Nixon, et al., Drugs Exptl. Clin. Res.,17:8, 389-393 (1991).
Davis, et al., Tetrahedron Letters,31:36, 5201-5204 (1990).
Brenner, etal., Tetrahedron Letters,44:10, 2887-2892 (1988).
Joyce, et al., The Journal of Organic Chemistry,52:7, 1177-1186 (1987).
Buchdunger, et al., Proc. Natl. Acad. Sci. USA,91, 2334-2338 (Mar. 1994).
Kobayashi, et al., The American Physiological Society,H1214-H1220 (1994).
Felsenstein, et al., Neuroscience Letters,174 173-176 (1994).
Demaerschalck, et al., Biochimica et Biophysica Acta,1181 214-218 (1993).
Shimohama, et al., Neurology,43 1407-1413 (1993).
Ansell, et al., Journal of Chemical Society,1788-1795 (1957).
Rudloff, et al.,Canadian Journal of Chemistry,35 315-321 (1957).
Tius, et al., J. Am. Chem. Soc.,108 1035-1039 (1986).
Gillet, et al., Synthesis,355-360, (May 1986).
DeCamp Schuda, et al., Synthesis,309-312, (Apr. 1986).
Kaneko, et al., Tetrahedron Letters,26, 4015-4017 (1985).
Edge, et al., Chemistry & Industry,18:130, (Feb. 1991).
Steglich, et al.,Angew: Chem. Int. Ed. Engl.,19:(6):459-460 (1980).
Harris, et al.,Tetrahedron Letters,34 (51) : 8361-8364 (1993).
Bergman, et al.,Tetrahedron Letters,28: (38) : 4441-4444 (1987).
Behling, et al.,Tetrahedron Letters,30: (1) : 27-30 (1989).
Alexakis, et al.,Tetrahedron Letters,45: (19) : 6197-6202 (1989).
Lipshutz, et al.,Tetrahedron Letters,29: (8) : 893-896 (1988).
Fieser and Fieser, Reagents for Organic Synthesis,XII, John Wiley & Sons, p. 108 (1986).

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