Synthesis of bisindolylmaleimides

Details Synthesis of bisindolylmaleimides Synthesis of bisindolylmaleimides

1997-08-22

1999-11-23

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548428, 540472, C07D40314, C07D49814

Patent

active

059903198

ABSTRACT:
The present invention provides for the reaction of optionally substituted indole-3-acetamides with optionally substituted methyl indole-3-glyoxyl reagent to prepare potent PKC inhibitors. The reaction is a very efficient and robust macrocyclization methodology.

REFERENCES:
patent: 5057614 (1991-10-01), Davis et al.
patent: 5339712 (1995-03-01), Hill
patent: 5541347 (1996-07-01), Faul et al.
Davis et al., Inhibitors of Protein Kinase C. 1. 2,3-Bisarylmaleimides, J. Med. Chem. Jan. 1992, vol. 35, No.1, pp. 177-184.

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