Synthesis of bis (morpholinomethyl) derivatives of tricyclic bis

Details Synthesis of bis (morpholinomethyl) derivatives of tricyclic bis Synthesis of bis (morpholinomethyl) derivatives of tricyclic bis

1985-06-27

1992-07-14

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D41300

Patent

active

051304260

ABSTRACT:
Bis(morpholinomethyl) derivatives of tricyclic bisdioxopyperzaines of the formula ##STR1## wherein R is H, ##STR2## R' is H, lower alkyl groups (straight or branched chain of 1 to 6 carbon atoms) and the processes for the syntheses thereof are provided.

REFERENCES:
Herman et al, 19 Adv. Pharmacol. and Chemother., 249 (1982).
Witiak et al, 21 J. Med. Chem., 1194 (1978).
Witiak et al., 24 J. Med. Chem., 1329 (1981).
Ren et al., Kexue Tongbao, 1980:25, 189.
Ren, abstract of Japanese patent Application No. 58-132657, published in Central Patents Index-Derwent Publications, London, England, 1985, Week 8512, p. 10 on about May 1, 1985.
Ren abstract, At--2153(MST-02) presented at the 14th International Congress of Chemotherapy, Kyoto, Japan, 1985.

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