Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides

Details Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides Synthesis of bicyclic aromatic sulfonic acids sulfonyl chlorides

1992-08-19

1995-02-07

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

508718, 549350, 549429, C07D23304

Patent

active

053876814

ABSTRACT:
This invention provides a novel process for the synthesis of bicyclic aromatic sulfonic acids employing reacting a bicyclic aromatic compound with sulfur trioxide-N,N-dimethylformamide complex in the presence of a water miscible, non-reactive solvent. The resulting sulfonic acid may be converted into the corresponding sulfonyl halide by the reaction with a thionyl halide. This invention further provides a novel process for the synthesis of bicyclic aromatic sulfonamides employing the reaction conditions described supra followed by an ammonolysis or amination.

REFERENCES:
patent: 4560771 (1985-12-01), Fory
patent: 4659709 (1987-04-01), Harada et al.
patent: 4918206 (1990-04-01), Harada et al.
Kurzer, Chemical Reviews, 50:1-19 (1952).
Shah, et al., Journal of Medicinal Chemistry, 12:938 (1969).
Kittila, Dimethylformamide Chemical Uses, E. I. DuPont DeNemour and Co., 76, 77 (1967).
Breuer, et al., Chimie Therapeutique, 659 (1979).
Marshall, et al., Journal of Organic Chemistry, 23:927 (1958).
Marshall, et al., Journal of Medicinal Chemistry, 6:60 (1963).

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