Synthesis of .beta.-lactams having a substituted hydroxymethylen

Details Synthesis of .beta.-lactams having a substituted hydroxymethylen Synthesis of .beta.-lactams having a substituted hydroxymethylen

1979-10-04

1981-08-11

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

2602452R, 2602452T, 2602453, 544 16, 544 26, 544 27, 424246, 424270, 424271, C07D49900, C07D50100

Patent

active

042835313

ABSTRACT:
.beta.-Lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group are prepared by reaction of an .alpha.-halo-.beta.-lactam with zinc or zinc amalgam in an anhydrous aprotic medium to produce an intermediate which in situ reacts with an appropriate aldehyde or ketone.
Also described are novel penicillins and cephalosporins having useful antibacterial activity.

REFERENCES:
patent: 4168314 (1979-09-01), Christensen et al.
patent: 4172144 (1979-10-01), Bosffard et al.
patent: 4172895 (1979-10-01), Christensen et al.

Affiliated with

Also associated with

Rating

Synthesis of .beta.-lactams having a substituted hydroxymethylen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of .beta.-lactams having a substituted hydroxymethylen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of .beta.-lactams having a substituted hydroxymethylen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1026921