Synthesis of beta-lactam compounds

Details Synthesis of beta-lactam compounds Synthesis of beta-lactam compounds

1992-07-01

1993-06-01

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49900

Patent

active

052159973

ABSTRACT:
The invention relates to an improved process for the preparation of compounds of formula ##STR1## or salts thereof, starting from compounds of formulae ##STR2## via compounds of formulae ##STR3## in which compounds R.sub.1 is hydrogen or lower alkyl, R.sub.2 is an organic radical which may carry a functional group which may be protected by a customary protective group R.sub.2.sup.o, R.sub.3 is hydrogen or a customary carboxyl protective group R.sub.3.sup.o, W is a group which can be replaced by a thiocarboxylic acid radical of formula III, and Z is oxygen or sulfur.

REFERENCES:
patent: 4347183 (1982-08-01), Afonso et al.
patent: 4540579 (1985-09-01), Afonso et al.
patent: 4656165 (1987-04-01), Lang
patent: 4962196 (1990-10-01), Hungerbuhler et al.
patent: 5153315 (1992-10-01), Hungerbuhler et al.

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