Synthesis of .beta.-lactam antibacterials using soluble side cha

Details Synthesis of .beta.-lactam antibacterials using soluble side cha Synthesis of .beta.-lactam antibacterials using soluble side cha

1998-10-22

2000-12-05

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound having a 1-thia-4-aza-bicyclo

435 47, 435 46, 435244, C12P 3700

Patent

active

061565342

ABSTRACT:
Disclosed is a process for the synthesis of .beta.-lactam antibacterials using soluble side chain esters in the presence of enzyme acylase. Also disclosed are novel esters useful as reactants in said process.

REFERENCES:
patent: 4340672 (1982-07-01), Kondo
Fernandez-Lafuente et al., Synthesis of antibiotics (cephaloglycin) catalyzed by penicillin G acylase: Evaluation and optimizaiton of different synthetic approaches. Enzyme and Microbial Technology, 1996. vol. 19, pp. 9-14.

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