Synthesis of benzo fused heterocyclic sulfonyl chlorides

Details Synthesis of benzo fused heterocyclic sulfonyl chlorides Synthesis of benzo fused heterocyclic sulfonyl chlorides

1998-05-19

2000-10-31

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548199, 548568, 549362, 549408, 549429, 549462, C07D27762, C07D20718, C07D31916, C07D30779

Patent

active

061405051

ABSTRACT:
A process for preparing a benzo fused heterocyclic sulfonyl halide comprising reacting a benzo fused heterocyclic compound with an SO.sub.3 complex in the presence of a water immiscible, non-reactive solvent, at a temperature of from about 0.degree. C. to about 75.degree. C., cooling, if necessary, to a temperature of from about -25.degree. C. to about 65.degree. C. and then adding oxalyl halide.

REFERENCES:
patent: 5387681 (1995-02-01), Miller et al.
patent: 5756533 (1998-05-01), Getman et al.
The Merck Index, Eleventh Edition, Susan Budavari Editor pp. 598, 954, 1516, 1501, 1449, 1989.
Hartman et al., "4-Substituted Thiophene- and Furan-2-sulfonamides as Topical Carbonic Anhydrase Inhibitors," J. Med. Chem., 1992, 35, 3822-3831.
Hartman et al., "Synthesis and Derivatization of Novel 4-Aroylthiophene- and Furan-2-sulfonamides," J. Heterocyclic Chem., 1989, 26, 1793-1798.
Gorge D. Harman and Wasyl Halczenko, Synthesis and Derivatization of Novel 4-Aroylthiophene and furan-2-sulfonamides, J. Heterocyclic Chem., 26, pp. 1793-1798, Dec. 1989.
PCT/US99/07047 International Search Report.

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