Synthesis of asparagine-linked glycopeptides on a polymeric soli

Details Synthesis of asparagine-linked glycopeptides on a polymeric soli Synthesis of asparagine-linked glycopeptides on a polymeric soli

1995-06-07

1997-10-21

Cain, Edward J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Peptides containing saccharide radicals, e.g., bleomycins, etc.

536 172, 536 175, 536 179, 536 182, A61K 3702, C07K 900

Patent

active

056797699

ABSTRACT:
The present invention provides a process for synthesizing a glycopeptide having the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each independently H, OH, OR.sup.1, NH.sub.2, NHCOR.sup.i, F, CH.sub.2 OH, CH.sub.2 OR.sup.i, or a substituted or unsubstituted linear or branched chain alkyl, arylalkyl or aryl group, where R.sup.i is H, CHO, CO.sub.2 R.sup.ii, a linear or branched chain alkyl, arylalkyl or aryl group, or an oligosaccharide moiety, etc., wherein R.sub.0 is H, a linear or branched chain alkyl, arylalkyl or aryl group; wherein R.sub.10 is a substituted or unsubstituted linear or branched chain acyl, arylacyl or acid side-chains, and denotes position from the C-terminus, wherein a, b, c, h, i, j, r, s and t are each independently an integer between about 0 and about 3; wherein m and n are each independently an integer between about 0 and about 5; and wherein x, x'(N), y and y'(N) are each independently an integer between about 0 and,about 25; such glycopeptides being useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.

REFERENCES:
patent: 5185320 (1993-02-01), Trani et al.
patent: 5198418 (1993-03-01), Malabarba et al.
patent: 5302582 (1994-04-01), Vertesy et al.
patent: 5451570 (1995-09-01), Nadkasni et al.
patent: 5508387 (1996-04-01), Tang et al.

Affiliated with

Also associated with

Rating

Synthesis of asparagine-linked glycopeptides on a polymeric soli does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of asparagine-linked glycopeptides on a polymeric soli, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of asparagine-linked glycopeptides on a polymeric soli will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1007620