Synthesis of aryl serines

Details Synthesis of aryl serines Synthesis of aryl serines

1998-03-26

2000-05-02

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

540 27, 540 29, 540 39, 540115, 540160, C07C22928

Patent

active

060574739

ABSTRACT:
Anthraquinone chiral ligands (AQN) are used in asymmetric aminohydroxylation addition reactions of cinnamate based olefins for synthesizing aryl serines. The anthraquinones impart a reverse regioselectivity as compared to the commonly employed phalazine chiral ligands (PHAL). Carbamates are employed as the oxidant nitrogen source. The yields and enantiomeric efficiencies are Excellent. .beta.-Hydroxyamines are obtained by deprotecting the corresponding .beta.-hydroxycarbamate.

REFERENCES:
patent: 5767304 (1998-06-01), Sharpless et al.

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