Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazol

Details Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazol Synthesis of aryl glucuronide of 2-hydroxy-N- (5-nitro-2-thiazol

1998-07-13

1999-07-20

Lee, Howard C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514371, 536 41, 536 176, 548146, 548192, A61K 3170, A61K 31425

Patent

active

059256222

ABSTRACT:
An aryl glucuronide of 2-hydroxy-N-(5-nitro-2-thiazolyl)benzamide, preferably an O-aryl glucuronide, as well as methods for the convenient synthesis of these aryl glucuronides, highly stable and low toxicity pharmaceutical composition containing these aryl glucuronides, and methods for use of these pharmaceutical compositions, for example, for treatment of inflammation, infections, etc.

REFERENCES:
patent: 3496187 (1970-02-01), Bruderlein et al.
patent: 3950351 (1976-04-01), Rossignol et al.
patent: 5578621 (1996-11-01), Rossignol
patent: 5747518 (1998-05-01), Yoshikawa et al.
patent: 5846347 (1999-01-01), Hashiguchi et al.
patent: 5859308 (1999-01-01), Rossignol
Deshpande et al. "Aryl 5-Nitro-2-thiazolyl Sulfides, Sulfones and Esters as Potential Antibacterials", J. Prak. Chem., vol. 316(2): 349-352, 1974.
Goodman & Gilman's The Pharmacological Basis of Therapeutics, Ninth Ed., pp. 11-14, 1996.

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