Synthesis of antitumor alkaloid deoxyharringtonine and its precu

Details Synthesis of antitumor alkaloid deoxyharringtonine and its precu Synthesis of antitumor alkaloid deoxyharringtonine and its precu

1974-12-20

1976-05-25

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424274, C07D49114

Patent

active

039593126

ABSTRACT:
The alkaloid deoxyharringtonine and its precursor 3'-O-(5-methyl-2-oxohexanoyl)-cephalotaxine were synthesized according to the following preferred series of reactions: Ethyl t-butyl oxalate + 1-lithio-3-methylbut-1-yne .fwdarw. t-butyl 5-methyl-2-oxohex-3-ynoate .fwdarw. t-butyl 5-methyl-2-oxohexanoate .sup.-trifluoroacetic acid 5-methyl-2-oxohexanoic acid .sup.(COCl).sbsp.2 5-methyl-2-oxohexanoyl chloride .sup.cephalotaxine 3'-O-(5-methyl-2-oxohexanoyl)-cephalotaxine .sup.lithio methyl acetate deoxyharringtonine.

REFERENCES:
patent: 3870727 (1975-03-01), Powell et al.

Affiliated with

Also associated with

Rating

Synthesis of antitumor alkaloid deoxyharringtonine and its precu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Synthesis of antitumor alkaloid deoxyharringtonine and its precu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of antitumor alkaloid deoxyharringtonine and its precu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-905252