Synthesis of an intermediate for the preparation of 5,6-dihydro-

Details Synthesis of an intermediate for the preparation of 5,6-dihydro- Synthesis of an intermediate for the preparation of 5,6-dihydro-

1995-04-26

1996-11-12

Dees, Jose e G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 23, C07D33318, C07D49504

Patent

active

055741762

ABSTRACT:
This invention is concerned with an improved process for the synthesis of and intermediate en route to 5,6-dihydro-(s)-4-(ethylamino)-(s)-6-methyl-4h-thieno[2,3-b]thiopyran-2-su lfonamide 7,7-dioxide and related compounds. The instant process reduces the reaction time for the synthesis of the key intermediate from 3 to 4 days to from about 2 to about 4 hours while retaining the high enantiomeric purity of the product.

REFERENCES:
patent: 4113968 (1978-09-01), Mori et al.
patent: 4797413 (1989-01-01), Baldwin et al.
patent: 4968814 (1990-11-01), Blacklock et al.
patent: 4968815 (1990-11-01), Blacklock et al.
Blacklock, T. J. et al., J.Org. Chem., 58, pp. 1672-1679 (1993). III.

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