Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing
Patent
1979-11-01
1985-08-20
Hines, Robert V.
Organic compounds -- part of the class 532-570 series
Organic compounds
Amino nitrogen containing
564373, C07C10200, C07C 8728
Patent
active
045365997
ABSTRACT:
An amine of the formula, ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each hydrogen, alkyl or the like and n is 1, 2 or 3, including .alpha.-phenyl-.beta.-(p-tolyl)-ethylamine, which is useful as an optically resolving agent, an intermediate of medicines and the like, is effectively produced by a novel process comprising hydrolysis of the corresponding nitrile of the formula, ##STR2## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are the same as above, followed by alkali-decomposition of the resulting amide of the formula, ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and n are the same as above. An amide including the above one is effectively produced by hydrolysis of the corresponding nitrile in the presence of a base and hydrogen peroxide using an organic quaternary ammonium salt and/or a tertiary amine as a catalyst.
REFERENCES:
patent: 3594401 (1971-07-01), Cavalla et al.
patent: 3597458 (1971-08-01), Nakamura et al.
patent: 3657440 (1972-04-01), Werner
patent: 3707515 (1972-12-01), Huebner
patent: 3739019 (1973-06-01), Ueda et al.
patent: 3766194 (1973-10-01), Huebner
patent: 4082749 (1978-04-01), Seeger et al.
Adams et al., "Organic Reactions", vol. III, pp. 268-269, 273-274, and 280-281, (1956).
Seiji et al., "Chemical Abstracts", vol. 70, Section No. 87346j (1969).
Meyer et al., "Chemical Abstracts", vol. 56, p. 5882f, (1962).
Asami, "Chemical Abstracts", vol. 56, p. 403g, (1962).
Katsura Tadashi
Masuko Fujio
Hines Robert V.
Sumitomo Chemical Company Limited
LandOfFree
Synthesis of amine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Synthesis of amine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Synthesis of amine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-562188